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KMID : 0950619960050010071
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Journanl of Allied Health Sciences
1996 Volume.5 No. 1 p.71 ~ p.85
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Evaluation of IgG and IgM Determinations by New IFCC(CRM470) Reference Preparations for Proteins in Human Serum
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Lee Chang-Kyu
Lee Seung-Gwan
Ryu Jung-Rok
Kim Sang-Sup
Nam Hyun-Chul
Park Eun-Byung
Kim Jai-Young
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Abstract
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Measuring proteins is unlike measuring ions and small molecules for which the chemical and physical properties are well understood. Assaying large proteins requires comparing the test sample with a reference materials. Quality Control surveys in recent years, in various parts of the world, have shown poor between laboratory agreement for measurments of immunoglobulins. Values for the commonly measured proteins may have varied a considerable amount among method depending on the protein measured and the standard materials by the manufacturer. The College of American Pathotogists and the Bureau Economic Communitaire de Reference of the European Economic Community have recently released Reference Preparation for Proteins in Human Serum(RPPHS). The assay for IgG and IgM using CRM470 standard were compared with conventional method. There was a good correlation among two methods. However, the mean value in IgG obtained by the CRM470 method was a slightly lower than that by the conventional method, but higher than that by the conventional method in IgM.
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